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"GHK influenced the expression of about 4,000 human genes, shifting their expression from a diseased or aged state toward a healthier profile." Pickart et al., BioMed Res Int (2014) Loading, Tapering, and Continuous Use# There is no loading phase

Standard protocols using 1 to 2 mg daily are operating at a tiny fraction of these thresholds

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In probing the pathway of celiac disease, researchers wondered if the seemingly minor modification of the gluten-derived peptides by tissue transglutaminase 2, which removes an amide group from specific glutamine residues, might actually be critical to the peptides immunogenicity